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Posted on 3rd Apr 2015 @ 7:36 AM
Recently, the international academic journal of nature communication published online a latest research progress of Chinese Academy of Medical Sciences and Beijing Union Medical College researchers regarding the application of monoclonal antibody therapy for the treatment of H7N9 bird flu virus, the study has important significance for the H7N9 bird flu virus prevention and treatment, prevention of pandemic H7N9 avian influenza virus . On February 2013, H7N9 avian influenza virus subtype appeared in East China, and then the human infection with H7N9 virus appeared in a short time , people infected with H7N9 bird flu could trigger fever, cough, sputum and other acute respiratory infectious disease symptoms and causing severe pneumonia, severe cases can lead to death.
Outbreak of H7N9 avian influenza viruses posed a serious threat to public health, but the current treatment strategies to prevent and control human infection with H7N9 avian influenza is still very limited.Researchers obtained peripheral blood mononuclear cells from the patients recovered from H7N9 avian influenza virus infection , and thus established the Fab phage antibody library, and screened out of two strains of human monoclonal antibodies. This two strains of monoclonal antibodies exhibited highly neutralizing activity against intracellular H7N9 virus , the researchers also found that two amino acid on receptor binding site , 186V and 226L were very crucial for hemagglutinin antigen of antibody binding virus .
They used mouse model to perform the study , proved before virus infection using these two strains of monoclonal antibodies could enhance the ability of immune system to against H7N9 virus and could significantly reduce the titer of pulmonary infection. However , using monoclonal antibody therapy after infection could also provide effective protection, reducing viral lethal effect. In summary, these discovered two strains of antibodies in this study may have an important role in the prevention and treatment of H7N9 avian influenza virus, while it also plays an important role in prevention of the pandemics of avian influenza virus .