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Gene editing technology could interfere the raging of "Aedes aegypti"

Posted on 2nd Apr 2015 @ 6:34 AM

   Researchers at US Rockefeller University by utilizing gene editing technology (CRISPR-Cas9) mastered how the deadly "Aedes aegypti" could spread disease, bite humans and other information, which is expected to conduct technical intervention. Related research result was published in the recent journal of "Cell report." CRISPR-Cas9 technique refers to utilized the target specificity to bring Cas9 nuclease to the specific target on genome, thereby cutting a specific gene locus. Traditionally, to understand the function of a gene, scientists will by "removing gene" to train a organism lacking the gene, and then examine changes in the organism's senses and behavior. With the rapid development of the CRISPR-Cas9 technology, researchers are able to carry out many organisms research .

    Currently , researchers at Rockefeller University applied this technology to an important species - the Aedes aegypti, the mosquito annually make tens of millions of people infected with chikungunya, yellow fever and dengue fever and other deadly diseases. Leslie Hall · B · Worth Neurogenetics , responsible for the study and Behavior Laboratory postdoctoral researcher Benjamin · J · Matthews said: "In order to understand how the female Aedes aegypti spread diseases, they need to know how they bite humans , how to choose water to spawn. Once you've mastered this information, it is expected to carry out technical interventions. "Currently, his team has been able to use the CRISPR-Cas9 technology to effectively produce targeted gene mutation and intervention effect based on several genes of this mosquito . He said the project's immediate goal is to understand , as a disease vector , how the different genes of Aedes aegypti effectively operated and produced accurate immune system .

    Worth Hauer laboratory personnel have been suspected that a specific genes can assist mosquito spread diseases, but also allowed it find the perfect place to lay eggs. "Prior to launch this project, we believe that numerous genes modifications in the laboratory mosquito genomes is a very difficult thing." Matthews said, to create different types of genes mutations, scientists will ever be able to rely on a technology capable of binding processed protein and designated removed specific DNA fragment , this process is both expensive and unreliable. "Now we can have a good control of the CRISPR-Cas9 targeted technology and point any gene ." Matthews added:. "Before CRISPR-Cas9 technologies emerged, there are m any interesting animal species are unable to be studied for humans . However this great technology has revolutionized biology development process, almost every organism experiment having applied the technology have achieved the intended effect. "