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Posted on 26th Mar 2015 @ 7:00 AM
Recently, scientists from the United States published their latest research progress in the prestigious international journal of nature medicine , they found that chronic viral infections such as HIV would lead to function decline in cytotoxic T lymphocyte, in the process , prostaglandin E2 (PGE2) related signaling pathway played an important promoting role , and therefore, inhibition of PEG2 or may be an effective means of treating chronic viral infections. Currently, there are more than 10% of the worldwide population are suffering from torment of the HIV, HCV and HBV and other chronic viral infections, these types of diseases are likely to lead to serious complications and they even result in death. Continuous antigenic stimulation may trigger the occurrence of function decline and cell death in virus-specific cytotoxic T lymphocytes (CTL), leading to the persistence of HIV, HCV and HBV and other viruses .
In addition, the antiviral CTL would spontaneously suppress their restriction effects on immune pathogens through raised inhibitory receptors, such as PD-1 . Finding and blocking these signaling pathways that induce CTL disorder may contribute to clearing the chronic viral infections. The researchers found that prostaglandin E2 (PGE2) receptors EP2 and EP4 would raise in the virus-specific CTL during the process of chronic lymphocytic choriomeningitis virus (LCMV) infection, inhibiting CTL survival and normal functioning. They proved that jointly blocking PGE2 and PD-1 signaling pathway had a good effect on improving the virus control, amplifying virus-specific CTL cells with normal function . In summary, the study proved that inhibition of PEG2 not only an independent treatment targeting chronic viral infections, but also capable of blocking the PD-1 signal to treat chronic viral infection, thereby , it has important applications.